منابع مشابه
Mutation and location important in cancer treatment.
Targeting drugs to mutations in cancer cells is a powerful application of precision medicine, but the histology approach should not be abandoned, according to fi ndings published in The New England Journal of Medicine. In a phase 2 “basket” trial, David Hyman (Memorial Sloan Kettering Cancer Center, New York, NY, USA) and colleagues tested the oral kinase inhibitor vemurafenib in cancers other ...
متن کاملEffect of chromosome location on bacterial mutation rates.
In previous comparisons of enterobacterial sequences, synonymous substitution rates were higher in genes closer to the replication terminus, suggesting that mutation rates increase with distance from the replication origin. In order to directly test for the effects of chromosomal location on the rates of point mutations, we assayed the reversion rates of two lacZ alleles inserted at four positi...
متن کاملMutation Rates and Gene Location: Some Like It Hot
PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...
متن کاملLocation, location, location...
Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
متن کاملLocation, location, location
Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2011
ISSN: 1059-7794
DOI: 10.1002/humu.21638